However these products are no longer under development. Hardware Įarly on, the company initially presented own-developed high-performance computing solutions, focusing on accelerating open source algorithms such as HMMER, Smith-Waterman and ClustalW, using FPGA technology. In 2020, CLC bio released a free plug-in that enables workflow execution on AWS directly from the CLC Genomics Workbench desktop software. In 2019, this platform was adapted for and approved for use in AWS GovCloud. In 2017, CLC bio launched their CLC Genomics Cloud Engine as a command-line driven platform for cloud-based bioinformatics workflow execution on Amazon Web Services. CLC Genomics Workbench 21.0.4 with CLC Microbial Genomics Module 21.0 (Redwood City, CA. Features include read mapping and de novo assembly of high-throughput sequencing data, whole-genome detection of SNPs and structural variations, ChIP-seq, RNA-Seq, small RNA analysis, genome finishing, microbial genomics, structural biology, and functions to analyze, visualize, and compare genomic, transcriptomic, and epigenomic data. HPV genomes from Papilloma Virus Episteme were customized and. pathway analysis, genomics, and other omics). Īs additional capabilities were added to the software platform, it was eventually split into several themed Workbenches and plugins with collections of features relevant to different applications (e.g. In 2010, CLC bio was notable as the first commercial platform for bioinformatics analysis that utilized a graphical user interface for building, managing, and deploying analysis workflows as well as command-line tools, a SOAP and REST API, and later, the ability to run containerized tools. CLC bio developed some of their own open source algorithms, as well as their own SIMD-accelerated implementations of several existing popular applications. Software ĬLC bio's main activities were in software development for desktop ( Mac OS X, Windows, and Linux), enterprise, and cloud software for analysis of biological data. ĬLC bio was acquired by QIAGEN in 2013 and merged into its bioinformatics research and development division with several other purchased platforms in 2014. By 2012, it had additional offices in Cambridge, Massachusetts, Tokyo, Taipei and Delhi, with staff largely from research backgrounds (30% having a PhD) and had built a userbase of around 250,000 users in both academic institutions and biotechnology companies. Its product's development was also partly funded by collaborating with researchers on grant-funded projects. Protein Analysis: visualize 3-D protein structure and analyze protein functions.CLC bio was a bioinformatics software company that developed a software suite subsequently purchased by QIAGEN.ĬLC bio started commercial activities on Januheadquartered in Aarhus, Denmark.Contig Assembly: easy assembly and edit chromatogram data into contigs by CAP3 algorithm.Sequence Search: comprehensive search of private databases for proprietary clone collections, and of public databases such as NCBI's Entrez system for sequence similarity and PubMed for citations.Multiple Sequence Alignment : by ClusterW algorithm with detailed statistics and visualization report.RE sites, drug resistance markers, promoters, tags, etc.), predict cloning results with Gel Simulation. In silico Cloning: quick selection of vectors with specificied features (e.g.Primers Design: single or batch design of amplification, sequencing, MultiPlex PC, RHybridization, Alignment PCR primers.For example CLC Main Workbench 20. Sequence Management: Analyze, create, map, edit, annotate, illustrate, share and publicize DNA and protein sequences. To cite a CLC Workbench or Server product, use the name of the product, the version number and add (QIAGEN) to it.Vector NTI Explorer: Molecular biology data retrieval and management.BioAnnotator: Functional annotation of DNA and protein sequences.GenomBench: Analysis and annotation of reference genomic DNA sequences. ContigExpress: DNA sequence assembly, SNP and mutation detection, and sequencing project management.AlignX: Multiple sequence alignment of proteins and DNAs.Vector NTI: Sequence creation, mapping, analysis, design, annotation, illustration.Check out CLC Genomics Workbench for similar functionalities. All support for Vector NTI software will end on December 31, 2020. Vector NTI has been discontinued by ThermoFisher as of December 31, 2019.
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